Office of Research and Development Publications

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Rager, J., M. Strynar, S. Liang, R. McMahen, A. Richard, C. Grukle, J. Wambaugh, K. Isaacs, R. Judson, A. Williams, AND J. Sobus. Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 88:269-280, (2016).

Richard, A., R. Judson, K. Houck, C. Grulke, P. Volarath, I. Thillainadarajah, C. Yang, J. Rathman, M. Martin, J. Wambaugh, T. Knudsen, K. Mansouri, J. Kancherla, G. Tier, A. Williams, S. Little, K. Crofton, AND R. Thomas. The ToxCast Chemical Landscape - Paving the Road to 21st Century Toxicology. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 29(8):1225-1251, (2016).

Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(2):323-339, (2016).

Dionisio, K., A. Frame, M. Goldsmith, J. Wambaugh, A. Liddell, T. Cathay, D. Smith, J. Vail, A. Ernstoff, P. Fantke, O. Jolliet, AND R. Judson. Exploring consumer pathways and patterns of use for chemicals in the environment. Toxicology Reports. Elsevier B.V., Amsterdam, Netherlands, 2:228-237, (2015).

Wetmore, B., John F. Wambaugh, B. Allen, S. Ferguson, M. Sochaski, R. Woodrow Setzer, Keith A. Houck, C. Strope, K. Cantwell, Richard S. Judson, E. LeCluyse, H. Clewell III, Russell S. Thomas, AND M. Andersen. Incorporating High-Throughput Exposure Predictions with Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 1-57, (2015).

Wambaugh, J., B. Wetmore, R. Pearce, C. Strope, R. Goldsmith, J. Sluka, A. Sedykh, A. Tropsha, S. Bosgra, I. Shah, R. Judson, R. Thomas, AND Woodrow Setzer. Toxicokinetic Triage for Environmental Chemicals. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 147(1):55-67, (2015).

Garcia, R., J. Ibrahim, J. Wambaugh, E. Kenyon, AND Woodrow Setzer. Identifiability of PBPK Models with Applications to Dimethylarsinic Acid Exposure. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. Springer, New York, NY, , 1-19, (2015).

Goldsmith, Rocky, Chris Grulke, R. Brooks, T. Transue, C. Tan, A. Frame, P. Egeghy, R. Edwards, D. Chang, R. Tornero-Velez, K. Isaacs, A. Wang, J. Johnson, K. Holm, M. Reich, J. Mitchell, D. Vallero, L. Phillips, M. Phillips, J. Wambaugh, R. Judson, T. Buckley, AND C. Dary. Development of a Consumer Product Ingredient Database for Chemical ExposureScreening and Prioritization. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 65:269-279, (2014).

WETMORE, B. A., J. F. WAMBAUGH, S. S. FERGUSON, L. LI, H. J. CLEWEL III, R. JUDSON, K. FREEMAN, W. BAO, M. A. SOCHASKI, T. CHU, M. B. BLACK, E. HEALY, B. ALLEN, M. E. ANDERSEN, R. D. WOLFINGER, AND R. S. THOMAS. Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays . TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 132(2):327-346, (2013).

Wetmore, B., B. Allen, H. Clewell III, T. Parker, John F. Wambaugh, L. Almond, M. Sochaski, AND Russell S. Thomas. Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 142(1):210-224, (2014).

Wambaugh, J., A. Wang, A. Frame, K. Dionisio, P. Egeghy, R. Judson, AND Woodrow Setzer. High Throughput Heuristics for Prioritizing Human Exposure to Environmental Chemicals. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 48:12760-12767, (2014).

WAMBAUGH, J. F., WOODROW SETZER, A. M. Pitruzzello, J. Liu, D. M. Reif, N. C. Kleinstreuer, N. Y. WANG, N. SIPES, M. T. MARTIN, K. DAS, J. C. DeWitt, M. STRYNAR, R. JUDSON, K. A. HOUCK, AND C. LAU. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):308-327, (2013).

Judson, R., K. Houck, M. Martin, T. Knudsen, R. Thomas, N. Sipes, I. Shah, J. Wambaugh, AND K. Crofton. In Vitro and Modeling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Program. BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. Blackwell Publishing, Malden, MA, 115(1):69-76, (2014).

WAMBAUGH, J. F., R. W. SETZER, D. REIF, S. GANGWAL, J. MITCHELLBLACKWOOD, J. A. ARNOT, O. JOLIET, A. FRAME, J. R. RABINOWITZ, T. B. KNUDSEN, R. S. JUDSON, P. P. EGEGHY, D. A. VALLERO, AND E. A. COHEN HUBAL. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project . Jerald Schnoor (ed.), ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 47(15):8479-8488, (2013).

GANGWAL, S., D. REIF, S. MOSHER, P. P. EGEGHY, J. F. WAMBAUGH, R. JUDSON, AND E. A. COHEN-HUBAL. Incorporating exposure information into the toxicological prioritization index decision support framework . SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier Ireland Limited, Limerick, Ireland, 435-436C:316-325, (2012).

WETMORE, B. A., J. F. WAMBAUGH, S. S. FERGUSON, M. A. SOCHASKI, D. M. ROTROFF, K. FREEMAN, H. J. CLEWELL III, D. J. DIX, M. E. ANDERSEN, K. A. HOUCK, B. ALLEN, R. S. JUDSON, R. SINGH, R. J. KAVLOCK, A. M. RICHARD, AND R. S. THOMAS. Integration of Dosimetry, Exposure and High-Throughput Screening Data in Chemical Toxicity Assessment. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 125(1):157-174, (2012).

WETMORE, B. A., J. F. WAMBAUGH, S. S. FERGUSON, M. A. SOCHASKI, D. ROTROFF, K. FREEMAN, H. J. CLEWELL III, D. J. DIX, M. E. ANDERSEN, K. A. HOUCK, B. ALLEN, R. JUDSON, R. SINGH, R. J. KAVLOCK, A. M. RICHARD, AND R. S. THOMAS. Response to “Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates”. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 128(1):297-299, (2012).

Tatum-Gibbs, K., K. DAS, M. STRYNAR, A. DELINSKY, J. F. WAMBAUGH, R. ZEHR, A. B. LINDSTROM, AND C. LAU. Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 281(1-3):48-55, (2011).

JACK, J., J. F. WAMBAUGH, AND I. A. SHAH. Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles. Online, BMC Systems Biology. BioMed Central Ltd, London, Uk, 5(109):1-13, (2011).

ROTROFF, D. M., B. A. WETMORE, D. J. DIX, S. S. FERGUSON, H. J. CLEWELL, K. A. HOUCK, E. L. LECLUYSE, M. E. ANDERSEN, R. JUDSON, C. M. SMITH, M. A. SOCHASKI, R. J. KAVLOCK, F. BOELLMANN, M. T. MARTIN, D. REIF, J. F. WAMBAUGH, AND R. S. THOMAS. Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening . TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 117(2):348-58, (2010).

SHAH, I. A., K. A. HOUCK, R. JUDSON, R. J. KAVLOCK, M. T. MARTIN, D. REIF, J. F. WAMBAUGH, AND D. J. DIX. Using Nuclear Receptor Activity to Stratify Hepatocarcinogens. Stefan Wolfl (ed.), PLOS ONE . Public Library of Science, San Francisco, CA, 6(2; (e14584)):1-11, (2011).

WAMBAUGH, J. F. AND I. A. SHAH. Simulating Microdosimetry in a Virtual Hepatic Lobule. PLOS Computational Biology. Public Library of Science, San Francisco, CA, 6(4):1-16, (2010).

SHAH, I. A. AND J. F. WAMBAUGH. Virtual Tissues in Toxicology. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART B: CRITICAL REVIEWS. Taylor & Francis, Inc., Philadelphia, PA, 13(2-4):314-328, (2010).

WAMBAUGH, J. F., H. A. BARTON, AND R. W. SETZER. Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. Springer, New York, NY, 35(6):683-712, (2008).

Lou, I., J. F. WAMBAUGH, C. LAU, R. HANSON, A. B. LINDSTROM, M. STRYNAR, R. ZEHR, R. W. SETZER, AND H. A. BARTON. Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice (J). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 107(2):331-41, (2009).